Chemical Constituents and Biological Activities of Mitrella Kentii (Blume) Miq. Leaf Oil
نویسندگان
چکیده
Chemical constituents and biological activities of the Mitrella kentii leaf oil were investigated in this study. Gas chromatography (GC) gas chromatography-mass spectrometry (GC-MS) used to determine chemical oil. The was evaluated for its ability inhibit prostaglandin E2 (PGE2) thromboxane B2 (TXB2) productions human whole blood using a radioimmunoassay technique. Its inhibitory effect on platelet-activating factor (PAF) receptor binding with rabbit platelets 3H-PAF as ligand free radical scavenging DPPH also investigated. Caryophyllene oxide (33.8%), E,Z-farnesol (6.9%), benzyl benzoate (6.5%) viridiflorol among major components Even though weak observed both PGE2 TXB2 assays, significant results obtained PAF inhibition 2,2-diphenyl-1-picrylhydrazyl (DPPH) IC50 value 6.6 µg/mL 155.6 respectively. These promising warrant development an anti-inflammatory agent.
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ژورنال
عنوان ژورنال: Jurnal sains kesihatan Malaysia =
سال: 2021
ISSN: ['2289-4535', '1675-8161']
DOI: https://doi.org/10.17576/jskm-2021-1901-17